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KMID : 0620920230550091982
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Experimental & Molecular Medicine
2023 Volume.55 No. 9 p.1982 ~ p.1995
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Functional significance of cholesterol metabolism in cancer: from threat to treatment
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Gerda Venter
Jin Xu
Wei Wang
Bo Zhang
Jiang Liu
Jialin Li
Hang Xu
Yingjun Zhao
Xianjun Yu
Si Shi
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Abstract
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Cholesterol is an essential structural component of membranes that contributes to membrane integrity and fluidity. Cholesterol homeostasis plays a critical role in the maintenance of cellular activities. Recently, increasing evidence has indicated that cholesterol is a major determinant by modulating cell signaling events governing the hallmarks of cancer. Numerous studies have shown the functional significance of cholesterol metabolism in tumorigenesis, cancer progression and metastasis through its regulatory effects on the immune response, ferroptosis, autophagy, cell stemness, and the DNA damage response. Here, we summarize recent literature describing cholesterol metabolism in cancer cells, including the cholesterol metabolism pathways and the mutual regulatory mechanisms involved in cancer progression and cholesterol metabolism. We also discuss various drugs targeting cholesterol metabolism to suggest new strategies for cancer treatment.
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KEYWORD
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Cancer
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